![]() ![]() If someone has trouble sleeping, experiences unpleasant thoughts, or struggles with muscle tension or spasms, they could benefit from Xanax as well. Since this medication promotes relaxation, it helps calm the body and mind. Why People Use Xanaxĭoctors prescribe Xanax to individuals who could benefit from its relaxing and calming properties. Whether psychological or physical, a dependence can cause an individual to take more than prescribed, or form a substance abuse addiction. Developing a dependence is one of the biggest risks when taking Xanax. Only a small number of individuals who took Xanax experienced them. Individuals who take Xanax may also experience some of these symptoms: ![]() This causes the calming effect that Xanax is known for. When an individual takes Xanax, the chemical alprazolam makes its way to the brain, where the substance interacts with specific receptors. It is even more dangerous to crush and snort Xanax. It’s extremely dangerous to drink alcohol or consume Opioids or other depressants while under the influence of Xanax, as this may cause slow and ineffective breathing, coma, and death. Users might feel sleepy or dizzy or have slowed motor skills. The risk of becoming addicted to Xanax is increased if you have a history of abusing other drugs or alcohol. There is no discussion of sample size or pharmacokinetics.The FDA says that there is risk for dependence, even if the drug is taken short term and at the prescribed dosage. As with lorazepam, sublingual alprazolam is basically equivalent to the oral dose.Ī third mention of sublingual lorazepam or alprazolam is from a letter to the editor and describes one author's experience.51 The author concludes that lorazepam or alprazolam tablets chewed or held under the tongue give patients relief from panic symptoms in as few as 2 minutes. Time of peak concentration was 1.17 hours sublingually and 1.73 hours orally. The mean peak plasma concentration for the sublingual dose was 17.3 nanograms per milliliter and 14.4 nanograms per milliliter for the oral dose. The kinetics of oral and sublingual alprazolam were studied in 13 fasting volunteers.50 A 1-milligram tablet was used for both the oral and sublingual administration, and blood samples were drawn at 5 minutes and then throughout a 48-hour period. The authors conclude that sublingual lorazepam, given on an empty stomach, could be substituted for both oral and intramuscular lorazepam. The systemic availability was 94.1% sublingual and 99.8% oral. Peak concentration occurred at 2.35 hours for the sublingual and 2.37 hours for the oral dose. The mean peak plasma concentration was 23.3 ng/mL for the sublingual dose vs. Blood samples were drawn at 5 minutes and then at intervals up to 48 hours for the 10 subjects. The pharmacokinetics of sublingual lorazepam were compared with intravenous, intramuscular, and oral lorazepam in 10 subjects.49 For sublingual and oral administration, patients were asked to fast overnight and then received two standard 1-milligram tablets that were held under the tongue for 15 minutes. Sublingual administration is reported infrequently, but three papers on alprazolam and lorazepam indicate that this is an effective route. According to this review, the recommended administration is undiluted diazepam intravenous solution inserted with a small syringe. Therapeutic levels were between 754 ng/mL and 98.5 ng/mL and were based on seizure control. Nasal administration of short-acting benzodiazepines (midazolam) are used for preanesthetic or anesthetic medication and can even be safely used in children.47 This route for psychiatric purposes is not reported.Ī review paper on the rectal administration on diazepam concludes that this is an excellent alternative for the management of seizures.48 The author reviewed eight papers, which concluded that rectally administered intravenous diazepam reaches therapeutic levels in 5 to 10 minutes. There are a few reports on the use of sublingual benzodiazepines and many on rectal administration of benzodiazepines. While there are no reports of nonenteral routes for buspirone, there are several benzodiazepines that can be administered intramuscularly or intravenously. Link above is about intranasal use of Benzos and interesting. Do not snort Xanax or any Benzo for that matter unless its Versed/Midazolam. ![]()
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